A Stroke Monitoring and Alert System for a Future Without Late
Presentation

Orestis Vardoulis, Ph.D.
Postdoctoral Research Fellow
Pediatric Surgery
Stanford University

Due to concerns about COVID-19, the seminar will be available in-person or via a zoom live stream. 

Meeting URL: http://stanford.zoom.us/j/490911167 
Dial: +1 650 724 9799 (US, Canada, Caribbean Toll) or +1 833 302 1536 (US, Canada, Caribbean Toll Free)
ID: 490 911 167

Tuesday, March 17, 2020
James H. Clark Center, S360
11:00am - 12:00pm Seminar & Discussion
12:00pm - 12:15pm Mingling (no refershments)


ABSTRACT
Stroke remains the fifth leading cause of death and the primary cause of long-term disability in the United States with annual costs exceeding $72 billion dollars. Despite revolutionary stroke treatment advances, mortality still exceeds 25% for large strokes, with only 10%-15% of eligible patients receiving optimal treatment. These poor outcomes are primarily driven by delays before arrival to the hospital and more specifically delays before the 9-1-1 call. Nighttime strokes (>25% - 30% of strokes), lack of recognition, and inability to communicate or move, all contribute to these pre 9-1-1 delays. However, most stroke victims, either demonstrate warning signs (e.g. transient ischemic attacks -TIA) or suffer from a condition predisposing them to a stroke, such as intracranial atherosclerosis or atrial fibrillation. To address this clinical need, we are developing a minimally-invasive, subcutaneously-insertable device for patients with identifiable high risk for stroke. It continuously monitors the patient and in the case of a stroke event, it immediately recruits resources to enable fast access to treatment. Our analysis of published outcome data shows that even by modestly shrinking emergency response time to 4 hours (from stroke onset to intervention), we can reduce the mortality associated with large strokes from 25% to 7% and increase independent living from 22% to 60% (all outcomes measured 90 days post stroke)


ABOUT ORESTIS VARDOULIS
Orestis Vardoulis, PhD is a Post-Doctoral researcher at the Stanford Department of Surgery / Pediatric Surgery. He received his Diploma in Mechanical Engineering from the Aristotle University in Thessaloniki, Greece. Orestis received his Ph.D. in Biotechnology and Bioengineering from Ecole Polytechnique Federal de Lausanne, Switzerland. Orestis has a decade of experience as a biomedical engineer. His research focuses on medical device innovation. He has worked on a wide range of projects in the intersection of cardiovascular biomechanics and non invasive health sensing. He has authored 20+ original scientific articles which have been published in leading, high-impact journals (including Nature Nanotechnology, Science Robotics and JMRM). He has also contributed in multiple intellectual property disclosures. At Stanford, he has been leading the development of novel medical device technologies leveraging his experience in flexible electronics, his deep understanding of cardiovascular pathophysiology and his affiliation with the Stanford Center for Biodesign.


Hosted by: Sanjiv Sam Gambhir, M.D., Ph.D.
Sponsored by the PHIND Center and Department of Radiology